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RECRUITING
NCT05480384
Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction
25 Enrollment(s)
2 Study location(s)
INTERVENTIONAL (PHASE2)
Esophageal Adenocarcinoma


Esophageal Cancer


HER-2 Protein Overexpression


Gastroesophageal-junction Cancer
ACTIVE_NOT_RECRUITING
NCT04556773
A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer
138 Enrollment(s)
37 Study location(s)
INTERVENTIONAL (PHASE1)
Metastatic Breast Cancer
RECRUITING
NCT06271837
A Study of T-DXd as Monotherapy or in Combination With Anti-cancer Agents in Patients With Selected HER2-expressing Tumors
175 Enrollment(s)
33 Study location(s)
INTERVENTIONAL (PHASE2)
Advanced Solid Tumors (Excluding Gastric Cancer and Breast Cancer)
RECRUITING
NCT06048718
T-DXd Therapy for HER2-low Breast Cancer Patients With Brain Metastases
27 Enrollment(s)
13 Study location(s)
INTERVENTIONAL (PHASE2)
Breast Cancer


Metastatic Breast Cancer
COMPLETED
NCT04989816
Study of T-DXd Monotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Gastric or GEJ Adenocarcinoma Who Have Received 2 or More Prior Regimens
95 Enrollment(s)
24 Study location(s)
INTERVENTIONAL (PHASE2)
Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
RECRUITING
NCT05034887
Phase 2 Study of Trastuzumab Deruxtecan in the Neoadjuvant Treatment, or Trastuzumab Deruxtecan Plus Capecitabine Plus Durvalumab(MEDI4736) in the Preoperative and Postoperative Adjuvant Treatment for Patients with HER2 Positive Gastric and Gastroesophageal Junction Adenocarcinoma
64 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE2)
Gastric Adenocarcinoma


Gastroesophageal Junction Adenocarcinoma
COMPLETED
NCT04744831
Trastuzumab Deruxtecan in Participants With HER2-overexpressing Advanced or Metastatic Colorectal Cancer
122 Enrollment(s)
63 Study location(s)
INTERVENTIONAL (PHASE2)
Advanced Colorectal Cancer
ACTIVE_NOT_RECRUITING
NCT03742102
A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
243 Enrollment(s)
32 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Triple Negative Breast Neoplasms