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NOT_YET_RECRUITING
NCT07597993
BEYOND Study: A Multicentre, Prospective, Observational Study of Real-world Treatment Patterns and Outcomes of Trastuzumab Deruxtecan in Patients With HR Positive, HER2-low or Ultra-low Metastatic Breast Cancer Previously Treated With Endocrine Therapy
109 Enrollment(s)
2 Study location(s)
OBSERVATIONAL (None)
Breast Cancer
SUSPENDED
NCT05372614
Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene
33 Enrollment(s)
18 Study location(s)
INTERVENTIONAL (PHASE1)
Metastatic Malignant Solid Neoplasm


Unresectable Malignant Solid Neoplasm
ACTIVE_NOT_RECRUITING
NCT04622319
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
1,600 Enrollment(s)
482 Study location(s)
INTERVENTIONAL (PHASE3)
HER2-Positive Primary Breast Cancer


Residual Invasive Breast Cancer
RECRUITING
NCT07582887
Impact of Genetic Variants on the Toxicity of Antibody-Drug Conjugates in Locally Advanced or Metastatic Breast Cancer: The Role of the UGT1A1 Gene as a Predictive Biomarker of Therapeutic Response
70 Enrollment(s)
1 Study location(s)
OBSERVATIONAL (None)
Breast Cancer


Metastatic Breast Cancer


Drug-Related Side Effects and Adverse Reactions


Pharmacogenetic Variant
RECRUITING
NCT07582835
Study of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty.
355 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE3)
Coronary Artery Disease


Percutaneous Coronary Intervention


Acute Coronary Syndromes


Antiplatelet Therapy


Single Antiplatelet Therapy


Coagulation Factors
RECRUITING
NCT07012031
Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation
37 Enrollment(s)
9 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Locally Advanced Lung Non-Small Cell Carcinoma


Metastatic Lung Non-Small Cell Carcinoma


Stage III Lung Cancer AJCC v8


Stage IV Lung Cancer AJCC v8
COMPLETED
NCT04687761
Clinical Trial to Assess the Safety and Tolerability of the Combination of Low-dose Cytarabine or Azacitidine Plus Venetoclax and Quizartinib in Newly Diagnosed AML Patients Aged Equal or More Than 60 Years Old
113 Enrollment(s)
15 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Leukemia, Myeloid, Acute


De Novo


Age More 60yr
RECRUITING
NCT06821191
Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI: The Switching Antiplatelet-8 (SWAP-8) Study
78 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE4)
Coronary Artery Disease