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RECRUITING
NCT05417594
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies
695 Enrollment(s)
32 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Advanced Solid Malignancies
ACTIVE_NOT_RECRUITING
NCT04493138
Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations
30 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Chronic Myelomonocytic Leukemia


Myelodysplastic Syndrome


Myeloproliferative Neoplasm


Recurrent Chronic Myelomonocytic Leukemia


Recurrent Myelodysplastic Syndrome


Recurrent Myeloproliferative Neoplasm
RECRUITING
NCT05372614
Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene
58 Enrollment(s)
18 Study location(s)
INTERVENTIONAL (PHASE1)
Metastatic Malignant Solid Neoplasm


Metastatic Pancreatic Adenocarcinoma


Stage III Pancreatic Cancer AJCC v8


Stage IV Pancreatic Cancer AJCC v8


Unresectable Malignant Solid Neoplasm


Unresectable Pancreatic Adenocarcinoma
NOT_YET_RECRUITING
NCT07852637
Edoxaban Versus Apixaban in Cancer-Associated Venous Thromboembolism
2,300 Enrollment(s)
12 Study location(s)
INTERVENTIONAL (PHASE4)
Venous Thromboembolism


Active Cancer
RECRUITING
NCT07701941
A Study of Patritumab Deruxtecan (HER3-DXd) in Combination With Trastuzumab Deruxtecan (T-DXd) in Participants With HR-Positive, HER2-Low or HER2-Ultralow Unresectable or Metastatic Breast Cancer
220 Enrollment(s)
72 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Hormone Receptor Positive


HER2-low or HER2-ultralow


Unresectable or Metastatic Breast Cancer
NOT_YET_RECRUITING
NCT07691489
A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer
27 Enrollment(s)
7 Study location(s)
INTERVENTIONAL (PHASE2)
Colorectal Cancer


Adenocarcinoma of the Colon


Adenocarcinoma of the Rectum
RECRUITING
NCT05868226
PRE-ISPY Phase I/II Oncology Platform Program
280 Enrollment(s)
10 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
HER2-positive Breast Cancer


Metastatic Cancer


Metastatic Breast Cancer


Metastatic


HER2-positive Metastatic Breast Cancer


HER2 Mutation-Related Tumors


HER-2 Protein Overexpression


HER2-negative Breast Cancer


Triple Negative Breast Cancer


HR Positive


Hormone Receptor-positive Breast Cancer


Estrogen Receptor Positive Tumor


Progesterone Receptor-positive Breast Cancer


Hormone Receptor Negative Breast Carcinoma


Solid Tumor


Solid Tumor, Adult


Solid Carcinoma


HER2 Low Breast Cancer


HER2 Low Breast Carcinoma


ER Positive Breast Cancer


PR-positive Breast Cancer


Minimal Residual Disease


Colo-rectal Cancer


Colon Cancer


Rectal Cancer


ctDNA Monitoring


Colorectal Neoplasms


Colonic Neoplasms


Rectal Neoplasms


Neoplasm, Residual


Adenocarcinoma of Colon


Adenocarcinoma
RECRUITING
NCT07152782
T-DXd With or Without Neratinib for HER2 Positive Breast Cancer With Brain Metastasis
202 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE2)
Breast Cancer With Brain Metastasis


HER2-positive Breast Cancer