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RECRUITING
NCT02390752
Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...
54 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1)
Neurofibroma, Plexiform


Precursor Cell Lymphoblastic Leukemia-Lymphoma


Leukemia, Promyelocytic, Acute


Sarcoma
COMPLETED
NCT07778407
TDXD in Metastatic HER2-Positive Breast Cancer
25 Enrollment(s)
1 Study location(s)
OBSERVATIONAL (None)
Breast Advanced Malignancies
RECRUITING
NCT07459673
HERizon-Breast: A ctDNA-Guided Adaptive Study of Sequential Anti-HER2 Therapies and CNS Prophylaxis to Induce Long-Term Remission
60 Enrollment(s)
7 Study location(s)
INTERVENTIONAL (PHASE2)
Breast Cancer


HER2-positive Breast Cancer


Breast Cancer Stage IV
ACTIVE_NOT_RECRUITING
NCT05993234
A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)
257 Enrollment(s)
39 Study location(s)
OBSERVATIONAL (None)
HER2-positive Advanced Gastric Cancer


HER2-positive Gastroesophageal Junction Adenocarcinoma
RECRUITING
NCT05614739
FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3
677 Enrollment(s)
82 Study location(s)
INTERVENTIONAL (PHASE1)
Urinary Bladder Neoplasms
Neoplasm Metastasis
Ureteral Neoplasms
RECRUITING
NCT03661307
Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome
73 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Acute Myeloid Leukemia


Myelodysplastic Syndrome


Recurrent Acute Myeloid Leukemia


Recurrent Myelodysplastic Syndrome


Refractory Acute Myeloid Leukemia
NOT_YET_RECRUITING
NCT07553390
Phase 1b Study Of TRICK-NK In Combination With T-Dxd In Treatment-Refractory Breast Cancers
60 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1)
Breast Cancer
RECRUITING
NCT06467357
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
620 Enrollment(s)
269 Study location(s)
INTERVENTIONAL (PHASE3)
Biliary Tract Cancer