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ACTIVE_NOT_RECRUITING
NCT04639219
A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations
102 Enrollment(s)
30 Study location(s)
INTERVENTIONAL (PHASE2)
Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast
COMPLETED
NCT06740825
Study to Assess the Effect of a CYP3A Weak Inducer Rufinamide on Quizartinib Pharmacokinetics in Healthy Subjects
32 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1)
Healthy Subjects
RECRUITING
NCT06740799
Assessment of Quizartinib Pharmacokinetic in Subjects With Severe Hepatic Impairment
12 Enrollment(s)
3 Study location(s)
INTERVENTIONAL (PHASE1)
Hepatic Impairment
RECRUITING
NCT06467357
Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer
620 Enrollment(s)
172 Study location(s)
INTERVENTIONAL (PHASE3)
Biliary Tract Cancer
RECRUITING
NCT05573893
PROVIDENCE - Prospective Non-interventional Study (NIS) to Examine Patient-reported Outcomes and Real-world Clinical Data in Patients With HER2-positive or HER2-low Unresectable or Metastatic Breast Cancer Treated With Trastuzumab Deruxtecan
800 Enrollment(s)
87 Study location(s)
OBSERVATIONAL (None)
Breast Neoplasms


Breast Cancer


Neoplasm Metastasis
TERMINATED
NCT04100135
GORE® CARDIOFORM Septal Occluder Migraine Clinical Study
7 Enrollment(s)
15 Study location(s)
INTERVENTIONAL (NA)
Migraine


Patent Foramen Ovale


PFO - Patent Foramen Ovale
ACTIVE_NOT_RECRUITING
NCT04784715
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
1,157 Enrollment(s)
284 Study location(s)
INTERVENTIONAL (PHASE3)
Breast Cancer; HER2-positive; Metastatic
ACTIVE_NOT_RECRUITING
NCT04538742
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
245 Enrollment(s)
72 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Metastatic Breast Cancer