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NOT_YET_RECRUITING
NCT07318389
ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer
100 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (EARLY_PHASE1)
Dynamic Tumor Resistance


Metastatic Colorectal Cancer
RECRUITING
NCT07137416
Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer
36 Enrollment(s)
2 Study location(s)
INTERVENTIONAL (PHASE1)
Anatomic Stage III Breast Cancer AJCC v8
Anatomic Stage IV Breast Cancer AJCC v8
Invasive Breast Carcinoma
Locally Advanced Breast Carcinoma
Metastatic Breast Carcinoma
Metastatic HER2-Low Breast Carcinoma
Metastatic HER2-Positive Breast Carcinoma
Metastatic Hormone Receptor-Positive Breast Carcinoma
Metastatic Malignant Solid Neoplasm
Metastatic Triple-Negative Breast Carcinoma
Unresectable Breast Carcinoma
Unresectable HER2-Low Breast Carcinoma
Unresectable HER2-Positive Breast Carcinoma
Unresectable Hormone Receptor-Positive Breast Carcinoma
Unresectable Malignant Solid Neoplasm
Unresectable Triple-Negative Breast Carcinoma
RECRUITING
NCT04379596
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
450 Enrollment(s)
100 Study location(s)
INTERVENTIONAL (PHASE2)
Gastric Cancer
RECRUITING
NCT07198724
ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer
65 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Metastatic Breast Cancer


HER2 Low Breast Carcinoma


HER2-negative Breast Cancer


Breast Cancer


Breast Cancer Female
RECRUITING
NCT05704829
NeoAdjuvant Therapy With Trastuzumab-deruxtecan Versus Chemotherapy+Trastuzumab+Pertuzumab in HER2+ Early Breast Cancer
702 Enrollment(s)
44 Study location(s)
INTERVENTIONAL (PHASE2)
HER2-positive Early Breast Cancer
ACTIVE_NOT_RECRUITING
NCT05113251
Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
927 Enrollment(s)
145 Study location(s)
INTERVENTIONAL (PHASE3)
Breast Neoplasms


Breast Cancer


HER2-positive Early Breast Cancer
COMPLETED
NCT05035277
AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation
360 Enrollment(s)
3 Study location(s)
INTERVENTIONAL (PHASE3)
Aortic Stenosis
TERMINATED
NCT04100135
GORE® CARDIOFORM Septal Occluder Migraine Clinical Study
7 Enrollment(s)
15 Study location(s)
INTERVENTIONAL (NA)
Migraine


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