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RECRUITING
NCT05824975
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
358 Enrollment(s)
11 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Advanced Solid Tumor


Metastatic Solid Tumor


Soft Tissue Sarcoma (STS)


Platinum-resistant Ovarian Cancer (PROC)


Hepatocellular Carcinoma (HCC)


Colorectal Cancer (CRC)


HER2 Negative Breast Cancer


Cutaneous Melanoma


Renal Cell Carcinoma (RCC)
COMPLETED
NCT04989816
Study of T-DXd Monotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Gastric or GEJ Adenocarcinoma Who Have Received 2 or More Prior Regimens
95 Enrollment(s)
24 Study location(s)
INTERVENTIONAL (PHASE2)
Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
RECRUITING
NCT05034887
Phase 2 Study of Trastuzumab Deruxtecan in the Neoadjuvant Treatment, or Trastuzumab Deruxtecan Plus Capecitabine Plus Durvalumab(MEDI4736) in the Preoperative and Postoperative Adjuvant Treatment for Patients with HER2 Positive Gastric and Gastroesophageal Junction Adenocarcinoma
64 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE2)
Gastric Adenocarcinoma


Gastroesophageal Junction Adenocarcinoma
COMPLETED
NCT04744831
Trastuzumab Deruxtecan in Participants With HER2-overexpressing Advanced or Metastatic Colorectal Cancer
122 Enrollment(s)
63 Study location(s)
INTERVENTIONAL (PHASE2)
Advanced Colorectal Cancer
ACTIVE_NOT_RECRUITING
NCT06372483
Single Dose Trial of VMX-C001 in Healthy Subjects with and Without FXa Direct Oral Anticoagulant
40 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1)
Coagulation Disorder
RECRUITING
NCT05965479
Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer
25 Enrollment(s)
14 Study location(s)
INTERVENTIONAL (PHASE2)
Gastrooesophageal Cancer
RECRUITING
NCT04986579
Scalp Cooling in MBC
120 Enrollment(s)
2 Study location(s)
INTERVENTIONAL (PHASE2)
Metastatic Breast Cancer


Chemotherapy-induced Alopecia
RECRUITING
NCT06085755
Trastuzumab Deruxtecan(T-DXd) and Afatinib Combination in HER2-low Advanced Gastric Cancer
61 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Stomach Neoplasm