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RECRUITING
NCT07716189
Auricular Point Stimulation Plus Dexamethasone Versus Standard Antiemetic Regimen for Nausea and Vomiting Caused by Trastuzumab Deruxtecan
74 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE3)
Nausea and Vomiting Caused by Trastuzumab Deruxtecan
RECRUITING
NCT06912763
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
250 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE2)
Fibrosis Syndrome


Lymphedema


Head &Amp; Neck Cancer


Fibrosis
ACTIVE_NOT_RECRUITING
NCT05633979
Phase 1b Study of EZH1/2 Inhibitor Valemetostat in Combination With Trastuzumab Deruxtecan in Subjects With HER2 Low/Ultra-low/Null Metastatic Breast Cancer
17 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1)
Breast Cancer
NOT_YET_RECRUITING
NCT07701941
A Study of Patritumab Deruxtecan (HER3-DXd) in Combination With Trastuzumab Deruxtecan (T-DXd) in Participants With HR-Positive, HER2-Low or HER2-Ultralow Unresectable or Metastatic Breast Cancer
220 Enrollment(s)
1 Study location(s)
INTERVENTIONAL (PHASE1|||PHASE2)
Hormone Receptor Positive


HER2-low or HER2-ultralow


Unresectable or Metastatic Breast Cancer
RECRUITING
NCT07195149
Comparing High and lOw-dose asPirin With Dual anTIplatelet Therapy for Three Months Using prasUgrel and aSpirin Following Coronary Artery Bypass Grafting. (OPTIMUS-CABG Trial)
1,703 Enrollment(s)
18 Study location(s)
INTERVENTIONAL (PHASE3)
Chronic Coronary Syndrome


Stable Coronary Artery Disease CAD
RECRUITING
NCT07137416
Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer
36 Enrollment(s)
2 Study location(s)
INTERVENTIONAL (PHASE1)
Anatomic Stage III Breast Cancer AJCC v8


Anatomic Stage IV Breast Cancer AJCC v8


Invasive Breast Carcinoma


Locally Advanced Breast Carcinoma


Metastatic Breast Carcinoma


Metastatic HER2-Low Breast Carcinoma


Metastatic HER2-Positive Breast Carcinoma


Metastatic Hormone Receptor-Positive Breast Carcinoma


Metastatic Malignant Solid Neoplasm


Metastatic Triple-Negative Breast Carcinoma


Unresectable Breast Carcinoma


Unresectable HER2-Low Breast Carcinoma


Unresectable HER2-Positive Breast Carcinoma


Unresectable Hormone Receptor-Positive Breast Carcinoma


Unresectable Malignant Solid Neoplasm


Unresectable Triple-Negative Breast Carcinoma
ACTIVE_NOT_RECRUITING
NCT05048797
A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations
454 Enrollment(s)
130 Study location(s)
INTERVENTIONAL (PHASE3)
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
ACTIVE_NOT_RECRUITING
NCT04482309
A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors
477 Enrollment(s)
89 Study location(s)
INTERVENTIONAL (PHASE2)
Part 1: Bladder, Biliary Tract, Cervical, Endometrial, Ovarian, Pancreatic Cancer, Rare Tumors, Any Tumor Type Excluding Breast, Gastric, Colorectal Cancer
Part 2: HER2 Expressing/Amplified Solid Tumors Excluding Breast, Gastric, Colorectal Cancer